I'd definitely see that work Jonah.
Depends on the budget and on the angle (comedic, action, drama). But let's focus solely on the budget. These are some good possibilities imho.
Dario Argento, Alex De La Iglesia, Paul Verhoeven (Director)
Marco Leonardi, Vincent Cassell, Robert Carlyle (Lead Role)
Rutger Hauer, Frank Vincent, William Fichtner (Bad Guys)
Luis Guzman, Danny Trejo, Enrique Iglesias, Joaquin De Almeyda (Mexicans)
Porn stars (Girls)
Brian De Palma, Oliver Stone, Martin Scorsese (Director)
Johnny Depp, Christian Bale, Brad Pitt (Lead Role)
Robert De Niro, Ralph Fiennes, Jack Nicholson (Bad Guys)
Benicio Del Toro, Antonio Banderas, Javier Bardem (Mexicans)
Angelina Jolie, Monica Bellucci, Scarlett Johannson (Girls)
I'd like to see a spaghettiwestern directed by the Coen brothers or Takeshi Kitano. David Lynch would be interesting too.
Btw, Dennis Hopper should be in there, maybe a cameo of sorts. Danny Trejo should ALWAYS be in there. You name a more stereotypical Mexican looking dude.